ANTI-MALARIAL DRUG RESISTANCE

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with an increased risk of colorectal cancer in 8-10 years after disease onset. Current colitis treatment strategies do not offer a cure for the disease, but only treat the symptoms with limited success and dangerous side-effects. Also, there is no preventive treatment for either UC or colorectal cancer...

Current Status of Malaria and Anti-malarial Drug Resistance in Sri Lanka

Even though malaria continues to cause high morbidity and mortality in most of the malaria endemic countries in the world, it is currently not a major health problem in Sri Lanka. Despite the low malaria incidence, the development and spread of anti-malarial drug resistance, combined with a recent increase in the armed conflict hindering provision of effective health services will make it diffi...

Present Position of Anti-Malarial Drug Therapy in India

A new anti-malarial drug against murine malaria

Eosin B, a common laboratory dye has been earlier reported to have good anti protozoan properties in vitro. We studied this drug for its effect on a murine malaria strain, Plasmodium berghei (Pb) in vivo using different tests. Full suppressive 4 days Peter’s Test was used in infected outbred and inbred mice, using both ip and oral routes. Secondary biological assessment was carried out using do...

Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives

OBJECTIVES Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials ...